CobaltMaghrebV1, Main, Exploration, bibRecord, 000638

Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: Indolenyl sulfonamide derivatives

Identifieur interne : 000638 ( Main/Exploration ); précédent : 000637; suivant : 000639

Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: Indolenyl sulfonamide derivatives

Auteurs : Zahid H. Chohan [Pakistan] ; Moulay H. Youssoufi [Maroc] ; Aliasghar Jarrahpour [Iran] ; Taibi Ben Hadda [Maroc]

Source :

European journal of medicinal chemistry [ 0223-5234 ] ; 2010.

RBID : Pascal:10-0228800

Descripteurs français

Pascal (Inist)
- Antibactérien, Antifongique, Modèle moléculaire, Relation structure activité, Tautomère, Dérivé du benzène, Dérivé de l'isoxazole, Dérivé de la pyrimidine, Criblage virtuel, Bioinformatique, Composé aromatique, Synthèse chimique, Dérivé du thiazole, Aldimine, Antimicrobien, Toxicité, Artemia salina, Cytotoxicité, In vitro, Imine, Sulfonamide, Modélisation, Benzènesulfonamide(4-indol-3-ylméthylèneamino-N-thiazol-2-yl), Indole-3-carbaldéhyde dérivé, Benzènesulfonamide dérivé.

English descriptors

KwdEn :
- Aldimine, Antibacterial agent, Antifungal agent, Antimicrobial agent, Aromatic compound, Artemia salina, Benzene derivatives, Bioinformatics, Chemical synthesis, Cytotoxicity, Imine, In vitro, Isoxazole derivatives, Modeling, Molecular model, Pyrimidine derivatives, Structure activity relation, Sulfonamide, Tautomer, Thiazole derivatives, Toxicity, Virtual screening.

Abstract

Synthesis of seven new indolenyl sulfonamides, have been prepared by the condensation reaction of indole-3-carboxaldehyde with different sulfonamides such as, sulphanilamide, sulfaguanidine, sulfathiazole, sulfamethoxazole, sulfisoxazole, sulfadiazine and sulfamethazine. These synthesized compounds have been used as potential ligands for complexation with some selective divalent transition metal ions (cobalt, copper, nickel & zinc). Structure of the synthesized ligands has been deduced from their physical, analytical (elemental analyses) and spectral (IR, ¹H NMR and ¹³C NMR & UV-vis) data. All the compounds have also been assayed for their in vitro antibacterial and antifungal activities examining six species of pathogenic bacteria (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and six of fungi (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium soloni and Candida glabrata). Antibacterial and antifungal results showed that all the compounds showed significant antibacterial activity whereas most of the compounds displayed good antifungal activity. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.

Affiliations:

Iran, Maroc, Pakistan

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000095
to stream PascalFrancis, to step Curation: 000200
to stream PascalFrancis, to step Checkpoint: 000091
to stream Main, to step Merge: 000642
to stream Main, to step Curation: 000638

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: Indolenyl sulfonamide derivatives</title>
<author><name sortKey="Chohan, Zahid H" sort="Chohan, Zahid H" uniqKey="Chohan Z" first="Zahid H." last="Chohan">Zahid H. Chohan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, Bahauddin Zakariya University</s1>
<s2>Multan 60800</s2>
<s3>PAK</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Pakistan</country>
<wicri:noRegion>Multan 60800</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Youssoufi, Moulay H" sort="Youssoufi, Moulay H" uniqKey="Youssoufi M" first="Moulay H." last="Youssoufi">Moulay H. Youssoufi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratoire de Chimie des Matériaux, Université Med. Premier, Av. Mohammed VI</s1>
<s2>Elqodss, Oujda 60000</s2>
<s3>MAR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Maroc</country>
<wicri:noRegion>Elqodss, Oujda 60000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jarrahpour, Aliasghar" sort="Jarrahpour, Aliasghar" uniqKey="Jarrahpour A" first="Aliasghar" last="Jarrahpour">Aliasghar Jarrahpour</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Chemistry, College of Sciences, Shiraz University</s1>
<s2>Shiraz 71454</s2>
<s3>IRN</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Iran</country>
<wicri:noRegion>Shiraz 71454</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ben Hadda, Taibi" sort="Ben Hadda, Taibi" uniqKey="Ben Hadda T" first="Taibi" last="Ben Hadda">Taibi Ben Hadda</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratoire de Chimie des Matériaux, Université Med. Premier, Av. Mohammed VI</s1>
<s2>Elqodss, Oujda 60000</s2>
<s3>MAR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Maroc</country>
<wicri:noRegion>Elqodss, Oujda 60000</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0228800</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0228800 INIST</idno>
<idno type="RBID">Pascal:10-0228800</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000095</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000200</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000091</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000091</idno>
<idno type="wicri:doubleKey">0223-5234:2010:Chohan Z:identification:of:antibacterial</idno>
<idno type="wicri:Area/Main/Merge">000642</idno>
<idno type="wicri:Area/Main/Curation">000638</idno>
<idno type="wicri:Area/Main/Exploration">000638</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: Indolenyl sulfonamide derivatives</title>
<author><name sortKey="Chohan, Zahid H" sort="Chohan, Zahid H" uniqKey="Chohan Z" first="Zahid H." last="Chohan">Zahid H. Chohan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, Bahauddin Zakariya University</s1>
<s2>Multan 60800</s2>
<s3>PAK</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Pakistan</country>
<wicri:noRegion>Multan 60800</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Youssoufi, Moulay H" sort="Youssoufi, Moulay H" uniqKey="Youssoufi M" first="Moulay H." last="Youssoufi">Moulay H. Youssoufi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratoire de Chimie des Matériaux, Université Med. Premier, Av. Mohammed VI</s1>
<s2>Elqodss, Oujda 60000</s2>
<s3>MAR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Maroc</country>
<wicri:noRegion>Elqodss, Oujda 60000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jarrahpour, Aliasghar" sort="Jarrahpour, Aliasghar" uniqKey="Jarrahpour A" first="Aliasghar" last="Jarrahpour">Aliasghar Jarrahpour</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Chemistry, College of Sciences, Shiraz University</s1>
<s2>Shiraz 71454</s2>
<s3>IRN</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Iran</country>
<wicri:noRegion>Shiraz 71454</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ben Hadda, Taibi" sort="Ben Hadda, Taibi" uniqKey="Ben Hadda T" first="Taibi" last="Ben Hadda">Taibi Ben Hadda</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratoire de Chimie des Matériaux, Université Med. Premier, Av. Mohammed VI</s1>
<s2>Elqodss, Oujda 60000</s2>
<s3>MAR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Maroc</country>
<wicri:noRegion>Elqodss, Oujda 60000</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">European journal of medicinal chemistry</title>
<title level="j" type="abbreviated">Eur. j. med. chem.</title>
<idno type="ISSN">0223-5234</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">European journal of medicinal chemistry</title>
<title level="j" type="abbreviated">Eur. j. med. chem.</title>
<idno type="ISSN">0223-5234</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aldimine</term>
<term>Antibacterial agent</term>
<term>Antifungal agent</term>
<term>Antimicrobial agent</term>
<term>Aromatic compound</term>
<term>Artemia salina</term>
<term>Benzene derivatives</term>
<term>Bioinformatics</term>
<term>Chemical synthesis</term>
<term>Cytotoxicity</term>
<term>Imine</term>
<term>In vitro</term>
<term>Isoxazole derivatives</term>
<term>Modeling</term>
<term>Molecular model</term>
<term>Pyrimidine derivatives</term>
<term>Structure activity relation</term>
<term>Sulfonamide</term>
<term>Tautomer</term>
<term>Thiazole derivatives</term>
<term>Toxicity</term>
<term>Virtual screening</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Antibactérien</term>
<term>Antifongique</term>
<term>Modèle moléculaire</term>
<term>Relation structure activité</term>
<term>Tautomère</term>
<term>Dérivé du benzène</term>
<term>Dérivé de l'isoxazole</term>
<term>Dérivé de la pyrimidine</term>
<term>Criblage virtuel</term>
<term>Bioinformatique</term>
<term>Composé aromatique</term>
<term>Synthèse chimique</term>
<term>Dérivé du thiazole</term>
<term>Aldimine</term>
<term>Antimicrobien</term>
<term>Toxicité</term>
<term>Artemia salina</term>
<term>Cytotoxicité</term>
<term>In vitro</term>
<term>Imine</term>
<term>Sulfonamide</term>
<term>Modélisation</term>
<term>Benzènesulfonamide(4-indol-3-ylméthylèneamino-N-thiazol-2-yl)</term>
<term>Indole-3-carbaldéhyde dérivé</term>
<term>Benzènesulfonamide dérivé</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Synthesis of seven new indolenyl sulfonamides, have been prepared by the condensation reaction of indole-3-carboxaldehyde with different sulfonamides such as, sulphanilamide, sulfaguanidine, sulfathiazole, sulfamethoxazole, sulfisoxazole, sulfadiazine and sulfamethazine. These synthesized compounds have been used as potential ligands for complexation with some selective divalent transition metal ions (cobalt, copper, nickel & zinc). Structure of the synthesized ligands has been deduced from their physical, analytical (elemental analyses) and spectral (IR, <sup>1</sup>
H NMR and <sup>13</sup>
C NMR & UV-vis) data. All the compounds have also been assayed for their in vitro antibacterial and antifungal activities examining six species of pathogenic bacteria (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and six of fungi (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium soloni and Candida glabrata). Antibacterial and antifungal results showed that all the compounds showed significant antibacterial activity whereas most of the compounds displayed good antifungal activity. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.</div>
</front>
</TEI>
<affiliations><list><country><li>Iran</li>
<li>Maroc</li>
<li>Pakistan</li>
</country>
</list>
<tree><country name="Pakistan"><noRegion><name sortKey="Chohan, Zahid H" sort="Chohan, Zahid H" uniqKey="Chohan Z" first="Zahid H." last="Chohan">Zahid H. Chohan</name>
</noRegion>
</country>
<country name="Maroc"><noRegion><name sortKey="Youssoufi, Moulay H" sort="Youssoufi, Moulay H" uniqKey="Youssoufi M" first="Moulay H." last="Youssoufi">Moulay H. Youssoufi</name>
</noRegion>
<name sortKey="Ben Hadda, Taibi" sort="Ben Hadda, Taibi" uniqKey="Ben Hadda T" first="Taibi" last="Ben Hadda">Taibi Ben Hadda</name>
</country>
<country name="Iran"><noRegion><name sortKey="Jarrahpour, Aliasghar" sort="Jarrahpour, Aliasghar" uniqKey="Jarrahpour A" first="Aliasghar" last="Jarrahpour">Aliasghar Jarrahpour</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000638 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000638 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Terre
   |area=    CobaltMaghrebV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:10-0228800
   |texte=   Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: Indolenyl sulfonamide derivatives
}}

This area was generated with Dilib version V0.6.32.
Data generation: Tue Nov 14 12:56:51 2017. Site generation: Mon Feb 12 07:59:49 2024

	Serveur d'exploration sur le cobalt au Maghreb
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le cobalt au Maghreb

Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: Indolenyl sulfonamide derivatives

Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: Indolenyl sulfonamide derivatives

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri